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      The integrated National NeuroAIDS Tissue Consortium database: a rich platform for neuroHIV research

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          Abstract

          Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.

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          genenames.org: the HGNC resources in 2011

          Ruth Seal, Susan M. Gordon, Michael Lush … (2010)
          The HUGO Gene Nomenclature Committee (HGNC) aims to assign a unique gene symbol and name to every human gene. The HGNC database currently contains almost 30 000 approved gene symbols, over 19 000 of which represent protein-coding genes. The public website, www.genenames.org, displays all approved nomenclature within Symbol Reports that contain data curated by HGNC editors and links to related genomic, phenotypic and proteomic information. Here we describe improvements to our resources, including a new Quick Gene Search, a new List Search, an integrated HGNC BioMart and a new Statistics and Downloads facility.
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            HIV and aging: time for a new paradigm.

            Amy Justice (2010)
            The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectrum of disease experienced by those aging with HIV remains strongly influenced by HIV, its treatment, and the behaviors, conditions, and demographics associated with HIV infection. Our focus must shift from a narrow interest in CD4 counts, HIV-RNA, and AIDS-defining illnesses to determining the optimal management of HIV infection as a complex chronic disease in which the causes of morbidity and mortality are multiple and overlapping. We need a new paradigm of care with which to maximize functional status, minimize frailty, and prolong life expectancy. A composite index that summarizes a patient's risk of morbidity and mortality could facilitate this work and help chart its progress.
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              The National NeuroAIDS Tissue Consortium: a new paradigm in brain banking with an emphasis on infectious disease.

              S Morgello, B Gelman, P Kozlowski … (2001)
              The National NeuroAIDS Tissue Consortium (NNTC) was founded in 1998, in response to the scientific need for well-characterized central nervous system (CNS) and peripheral nervous system (PNS) tissues and fluids from HIV-infected individuals. In addition to performing the routine functions of non-transplant anatomic tissue banks, the Consortium offers a unique model for the integration of independent research entities in order to provide well-characterized tissues and fluids for the international research community. Herein, we describe the structure of the Consortium, pointing out the inherent strengths of linking together multiple independent sites for the purpose of banking HIV-infected nervous system tissues. We describe the neuropathology protocol that was adopted and successfully implemented at the four participating banks of the Consortium.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Database (Oxford)
                Journal ID (iso-abbrev): Database (Oxford)
                Journal ID (publisher-id): databa
                Title: Database: The Journal of Biological Databases and Curation
                Publisher: Oxford University Press
                ISSN (Electronic): 1758-0463
                Publication date Collection: 2019
                Publication date (Electronic): 08 January 2019
                Publication date PMC-release: 08 January 2019
                Volume: 2019
                Electronic Location Identifier: bay134
                Affiliations
                [1 ]Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
                [2 ]Bioinformatics and Systems Biology Core, University of Nebraska Medical Center, Omaha, NE, USA
                [3 ]Emmes Corporation, Rockville, MD, USA
                [4 ]Department of Medicine, University of California, San Diego, La Jolla, CA, USA
                [5 ]Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA
                Author notes
                Corresponding author: Tel: +402 559 4821; Fax: 402 559-7495; Email: hfox@ 123456unmc.edu
                Author information
                http://orcid.org/0000-0003-2032-374X
                Article
                Publisher ID: bay134
                DOI: 10.1093/database/bay134
                PMC ID: 6323298
                SO-VID: 0a731d79-9d41-4c03-ae28-87f224a02956
                Copyright © © The Author(s) 2019. Published by Oxford University Press.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 October 2018
                Date revision received : 26 November 2018
                Date accepted : 29 November 2018
                Page count
                Pages: 07
                Funding
                Funded by: National Institutes of Health 10.13039/100000002
                Award ID: U24MH100925
                Award ID: U24MH100928
                Award ID: U24MH100929
                Award ID: U24MH100930
                Award ID: U24MH100931
                Award ID: MH22005
                Award ID: HHSN271201000030C
                Award ID: HHS-N-271-2010-00036C
                Categories
                Subject: Database Update

                ScienceOpen disciplines: Bioinformatics & Computational biology
                Data availability:
                ScienceOpen disciplines: Bioinformatics & Computational biology

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