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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
October 1990
October 1990
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Abstract
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated
transcription factors. The receptor homologue is activated by a diverse class of rodent
hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome
proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic
effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic
risk to man.