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      Human papillomavirus 16-specific T-cell responses and spontaneous regression of anal high-grade squamous intraepithelial lesions.

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          Abstract

          Most anal cancers are attributable to persistent human papillomavirus type 16 (HPV-16) infection. The anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), frequently regresses spontaneously. We hypothesized that T-cell responses are associated with HSIL regression.

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          Author and article information

          Journal
          J. Infect. Dis.
          The Journal of infectious diseases
          1537-6613
          0022-1899
          Feb 1 2015
          : 211
          : 3
          Affiliations
          [1 ] Centre for Applied Medical Research, St Vincent's Hospital, Darlinghurst.
          [2 ] Royal Women's Hospital and University of Melbourne, Parkville.
          [3 ] The Kirby Institute, UNSW Australia, Sydney RPA Sexual Health, Royal Prince Alfred Hospital, Camperdown.
          [4 ] Melbourne Sexual Health Centre and University of Melbourne, Carlton, Victoria, Australia.
          [5 ] The Kirby Institute, UNSW Australia, Sydney.
          [6 ] Centre for Applied Medical Research, St Vincent's Hospital, Darlinghurst The Kirby Institute, UNSW Australia, Sydney.
          [7 ] Centre for Applied Medical Research, St Vincent's Hospital, Darlinghurst Western Sydney Sexual Health Centre and University of Sydney, Westmead, New South Wales.
          Article
          jiu461
          10.1093/infdis/jiu461
          25139018
          0ab4b5bf-0269-4fdd-9a33-1922d02b1549
          © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
          History

          HIV,T-lymphocytes,anal canal,cellular immunity,flow cytometry,human papillomavirus,intraepithelial neoplasia,precancerous conditions,spontaneous neoplasm regression

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