Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial.

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Abstract

Bronchopulmonary dysplasia, a major complication of extreme prematurity, has few treatment options. Postnatal steroid use is controversial, but low-dose hydrocortisone might prevent the harmful effects of inflammation on the developing lung. In this study, we aimed to assess whether low-dose hydrocortisone improved survival without bronchopulmonary dysplasia in extremely preterm infants.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Apr 30 2016

Volume: 387

Issue: 10030

Affiliations

[1 ] Neonatal Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Robert Debré, Université Paris Diderot, Sorbonne Paris Cité, INSERM U1141, Paris, France. Electronic address: olivier.baud@rdb.aphp.fr.

[2 ] Neonatal Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Robert Debré, Université Paris Diderot, Sorbonne Paris Cité, INSERM U1141, Paris, France.

[3 ] Neonatal Intensive Care Unit, Centre Hospitalier Corbeil-Essonnes, Sud Francilien, France.

[4 ] Neonatal and Pediatric Intensive Care Unit, CHR Saint-Denis, La Réunion, France.

[5 ] Neonatal Intensive Care Unit, Centre Hospitalier Intercommunal de Poissy, Poissy, France.

[6 ] Neonatal Intensive Care Unit, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalier Universitaire Hôpital Nord, Marseille, France.

[7 ] Neonatal Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Antoine Béclère, Paris, France.

[8 ] Neonatal intensive care unit, Centre Hospitalier de Pontoise, France.

[9 ] Neonatal Intensive Care Unit, Centre Hospitalier Universitaire Rennes, France.

[10 ] Neonatal Intensive Care Unit, Centre Hospitalier de Saint-Denis, France.

[11 ] Neonatal Intensive Care Unit, Centre Hospitalier Universitaire Grenoble, France.

[12 ] Unit of Clinical Epidemiology, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Robert Debré, Université Paris Diderot, Sorbonne Paris-Cité, INSERM U1123 and CIC-EC 1426, Paris, France.

Article

Publisher Item ID: S0140-6736(16)00202-6

DOI: 10.1016/S0140-6736(16)00202-6

PubMed ID: 26916176

SO-VID: 0ab95f62-f6ad-4d4b-8abf-a2d146f6200b

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