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      Plasma Levels of Main Granulocyte Components during Hemodialysis: Effects of Immunosuppression

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          Abstract

          Plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with α<sub>r</sub>proteinase inhibitor were investigated during hemodialysis in oliguric patients following cadaveric renal transplantation (CRT). The results were compared with those of patients undergoing regular hemodialysis treatment (RDT) using different membrane materials. In RDT patients, plasma lactoferrin levels increased from 61.9 ± 10.2 to 417.9 ± 96.7 using dialyzers made of cuprophane. Dialyzers made of polymethyl methacrylate induced an increase of lactoferrin from 166.6 ± 28.5 to 712.5 ± 165.9 and dialyzers made of polyacrylonitrile an increase from 122.6 ± 23.5 to 647.7 ± 203.6 ng/ml. In CRT patients, in contrast, plasma lactoferrin levels increased from 49.1 ± 10.9 to 199.6 ± 45.9 (cuprophane), from 30.1 ± 6.9 to 252.5 ± 46.9 (polymethyl methacrylate), and from 43.3 ± 9.1 to 174.2 ± 39.3 ng/ml (polyacrylonitrile). On the other hand, the plasma levels’ of myeloperoxidase and elastase in complex with αi-proteinase inhibitor increased comparably in both groups of patients. Our data suggest that immunosuppression might prevent degranulation of specific granules independently of the used dialyzer membrane material, whereas no effect was observed on two main components of azurophilic granules.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 46
          : 2
          : 161-166
          Affiliations
          Division of Nephrology, Department of Medicine, and Department of Surgery, University of Freiburg, FRG
          Article
          184333 Nephron 1987;46:161–166
          10.1159/000184333
          3037400
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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