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      Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing.

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          Abstract

          Interest in applying 21st-century toxicity testing tools for safety assessment of industrial chemicals is growing. Whereas conventional toxicology uses mainly animal-based, descriptive methods, a paradigm shift is emerging in which computational approaches, systems biology, high-throughput in vitro toxicity assays, and high-throughput exposure assessments are beginning to be applied to mechanism-based risk assessments in a time- and resource-efficient fashion. Here we describe recent advances in predictive safety assessment, with a focus on their strategic application to meet the changing demands of the chemical industry and its stakeholders. The opportunities to apply these new approaches is extensive and include screening of new chemicals, informing the design of safer and more sustainable chemical alternatives, filling information gaps on data-poor chemicals already in commerce, strengthening read-across methodology for categories of chemicals sharing similar modes of action, and optimizing the design of reduced-risk product formulations. Finally, we discuss how these predictive approaches dovetail with in vivo integrated testing strategies within repeated-dose regulatory toxicity studies, which are in line with 3Rs principles to refine, reduce, and replace animal testing. Strategic application of these tools is the foundation for informed and efficient safety assessment testing strategies that can be applied at all stages of the product-development process.

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          Author and article information

          Journal
          J. Am. Assoc. Lab. Anim. Sci.
          Journal of the American Association for Laboratory Animal Science : JAALAS
          1559-6109
          1559-6109
          Mar 2015
          : 54
          : 2
          Affiliations
          [1 ] Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan, USA. rssettivari@dow.com.
          [2 ] Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan, USA.
          Article
          4382627
          25836969
          0ad6308d-df84-407f-99d7-dfdbd265fbaa
          History

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