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      SARS-COV-2 SPIKE PROTEIN IMPAIRMENT OF ENDOTHELIAL FUNCTION DOES NOT IMPACT VACCINE SAFETY

      preprint
      1 , 2
      Zenodo
      Vascular Biology, Vascular Disease, SARS-CoV-2, Vaccines

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          Abstract

          Lei et al. [2021] showed the spike protein in SARS-CoV-2 alone was enough to cause damage to lung vascular endothelium. The authors noted that their results suggest that “vaccination-generated antibody and/or exogenous antibody against S protein not only protects the host from SARS-CoV-2 infectivity but also inhibits S protein-imposed endothelial injury”. We show that there is no known mechanism by which the spike protein impairment of endothelial function could reduce vaccine safety, and that vaccine safety data clearly shows that the spike proteins in vaccines does not reduce vaccine safety. Overall, we conclude that spike proteins encoded by vaccines are not harmful, and may be beneficial to vaccine recipients.

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          Author and article information

          Journal
          Zenodo
          2021
          25 May 2021
          Affiliations
          [1 ] Salk Institute for Biological Studies
          [2 ] University of San Francisco
          Article
          10.5281/zenodo.4784787
          0ae0380d-58c4-429b-a18f-83bca6a58b15

          Creative Commons Attribution 4.0 International


          Vascular Biology,Vaccines,SARS-CoV-2,Vascular Disease
          Vascular Biology, Vaccines, SARS-CoV-2, Vascular Disease

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