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      Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer

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          Abstract

          Early-phase trials with monoclonal antibodies targeting PD-1 (programmed cell death protein 1) and PD-L1 (programmed cell death 1 ligand 1) have demonstrated durable clinical responses in patients with non-small-cell lung cancer (NSCLC). However, current assays for the prognostic and/or predictive role of tumor PD-L1 expression are not standardized with respect to either quantity or distribution of expression.

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          Author and article information

          Journal
          JAMA Oncology
          JAMA Oncol
          American Medical Association (AMA)
          2374-2437
          January 01 2016
          January 01 2016
          : 2
          : 1
          : 46
          Affiliations
          [1 ]Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut2Department of Pathology, Yale University School of Medicine, New Haven, Connecticut
          [2 ]Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut
          [3 ]Department of Pathology, Yale University School of Medicine, New Haven, Connecticut
          [4 ]Department of Solid Tumor Oncology, Cleveland Clinic, Cleveland, Ohio
          [5 ]Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut
          Article
          10.1001/jamaoncol.2015.3638
          26562159
          © 2016

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