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      Necrotising enterocolitis.

      1 ,
      Lancet (London, England)
      Elsevier BV

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          Abstract

          Necrotising enterocolitis is one of the most common gastrointestinal emergencies in newborn infants. Here we review the epidemiology, clinical presentation, and pathophysiology of the disease, as well as strategies for diagnosis, management, and prevention. Necrotising enterocolitis is one of the most devastating and unpredictable diseases affecting premature infants. Despite decades of research, its pathogenesis remains unclear; diagnosis can be difficult; and treatment is challenging. We will need to improve our understanding of intestinal defences in premature infants, dietary and bacterial factors, and genetic effects that could predispose infants to necrotising enterocolitis before we can develop new strategies for prevention and treatment.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          Oct 07 2006
          : 368
          : 9543
          Affiliations
          [1 ] Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. patricia_lin@oz.ped.emory.edu
          Article
          S0140-6736(06)69525-1
          10.1016/S0140-6736(06)69525-1
          17027734
          0afe2e5b-0b37-4f09-af8f-7388277b1ff1
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