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      Technology overview and drug delivery application of proniosome.

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          Abstract

          Rapid advancement in the field of colloidal science has shown a great progress in the development of proniosome technology (PT) as an impending drug delivery system. PT is a valuable carrier system for delivery of hydrophobic as well as hydrophilic drugs. It is a liquid crystalline compact niosomal hybrid, which upon hydration gives niosomes. They can augment the bioavailability of encapsulated drug and provide better therapeutic activity in a controlled manner. Non-toxicity, penetration enhancing the effect of surfactant and modified drug release from the proniosomal transdermal gel has attracted a greater attention of formulation scientist toward PT. Free flowing dry proniosomal powder are suitable for unit dosage forms such as tablet and capsules. Proniosomes are auspicious drug delivery system for the future. Proniosomes-derived niosomes are a better alternative to the other vesicular system due to their superior physicochemical stability and effective drug delivery capability. The focus of this review is to bring out all the aspects of proniosomes including their different compositions, various methods of preparation, characterization and recent development in their therapeutic applications.

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          Author and article information

          Journal
          Pharm Dev Technol
          Pharmaceutical development and technology
          Informa Healthcare
          1097-9867
          1083-7450
          May 2017
          : 22
          : 3
          Affiliations
          [1 ] a Department of Pharmaceutics , Faculty of Pharmacy, Najran University , Najran , Saudi Arabia and.
          [2 ] b Department of Pharmaceutics and Industrial Pharmacy , Faculty of Pharmacy, Zagazig University , Zagazig , Egypt.
          Article
          10.3109/10837450.2015.1135344
          26794727
          0b0a90c0-3a8f-48a6-9b9f-c23225b605c8
          History

          Drug delivery,non-ionic surfactant,proniosome,provesicular system,slurry method,spray-coating method

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