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      Role of Atrial Natriuretic Peptides and Neuropeptide Y in Blood Pressure Regulation

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          Atrial natriuretic peptides (ANP) are released into the circulation in response to enhanced atrial stretching. These peptides not only have diuretic and natriuretic properties, but also exert a relaxing effect on the vasculature. Moreover, they antagonize the contractions induced by norepinephrine and angiotensin II. Neuropeptide Y (NPY) is also a vasoactive peptide. It is widely distributed throughout the central and peripheral nervous systems. NPY is coreleased with norepinephrine by perivascular nerve endings. At high concentrations, this peptide has a direct vasoconstrictor effect. In addition, it enhances the vascular effect of various agonists, including norepinephrine and angiotensin II. Both ANP and NPY have an inhibitory effect on renin secretion. This effect may have important implications for the role of these peptides in cardiovascular regulation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 34
          : 3-4
          : 161-165
          Division of Hypertension and Cardiovascular Research Group, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
          181817 Horm Res 1990;34:161–165
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 5
          Hormonal Control of Arterial Pressure and Water Electrolyte Metabolism


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