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      Glucagon Secretion in Chronic Pancreatitis

      , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Insulin, Glucagon, Pancreatitis, Glucose, Arginine

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          Abstract

          Plasma insulin, pancreatic glucagon and immunoreactive glucagon-like polypeptide of intestinal origin (enteroglucagon) have been measured in 10 patients with chronic pancreatitis and 5 normal subjects. Basal levels and changes following oral glucose (50 g) and an intravenous infusion of arginine (25 g in 30min) have been studied. In patients with chronic pancreatitis the plasma insulin response to oral glucose and intravenous arginine was reduced. Basal pancreatic glucagon was increased in the patients and increased further with oral glucose. During an arginine infusion the pancreatic glucagon showed a brisk early increase greater than that seen in the normal subjects. Basal enteroglucagon levels were significantly increased in chronic pancreatitis but response to oral glucose and arginine infusion were little different from those seen in the normal subjects.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1979
          1979
          25 November 2008
          : 11
          : 4
          : 203-212
          Affiliations
          Cobbold Laboratories, Thorn Institute of Clinical Science, The Middlesex Hospital Medical School, London
          Article
          179055 Horm Res 1979;11:203–212
          10.1159/000179055
          387567
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Original Paper

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