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      Complement regulators and inhibitory proteins.

      Nature reviews. Immunology

      metabolism, immunology, Receptors, Complement, Neoplasms, Macular Degeneration, Infection, Humans, Hemolytic-Uremic Syndrome, Glomerulonephritis, Membranoproliferative, Complement Inactivator Proteins, Complement C3-C5 Convertases, genetics, Complement Activation, Autoimmune Diseases, Animals

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          Abstract

          The complement system is important for cellular integrity and tissue homeostasis. Complement activation mediates the removal of microorganisms and the clearance of modified self cells, such as apoptotic cells. Complement regulators control the spontaneously activated complement cascade and any disturbances in this delicate balance can result in damage to tissues and in autoimmune disease. Therefore, insights into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases.

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          Journal
          19730437
          10.1038/nri2620

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