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      Neural crest cells contribute to normal aorticopulmonary septation.

      Science (New York, N.Y.)

      Animals, Aorta, embryology, Chick Embryo, Chimera, Coturnix, Heart, Heart Defects, Congenital, Humans, Lung, Neural Crest, physiology, Swine, Transposition of Great Vessels

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          Abstract

          By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

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          6844926

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