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Abstract
Polymerase chain reaction (PCR) assays are the most sensitive and specific method
to detect malaria parasites, and have acknowledged value in research settings. However,
the time lag between sample collection, transportation and processing, and dissemination
of results back to the physician limits the usefulness of PCR in routine clinical
practice. Furthermore, in most areas with malaria transmission, factors such as limited
financial resources, persistent subclinical parasitaemia, inadequate laboratory infrastructures
in the poorer, remote rural areas preclude PCR as a diagnostic method. Even in affluent,
non-endemic countries, PCR is not a suitable method for routine use. Nonetheless,
PCR could be clinically useful in selected situations.