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      The role of nanotechnology in the treatment of viral infections

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          Abstract

          <p class="first" id="d2697200e121">Infectious diseases are the leading cause of mortality worldwide, with viruses in particular making global impact on healthcare and socioeconomic development. In addition, the rapid development of drug resistance to currently available therapies and adverse side effects due to prolonged use is a serious public health concern. The development of novel treatment strategies is therefore required. The interaction of nanostructures with microorganisms is fast-revolutionizing the biomedical field by offering advantages in both diagnostic and therapeutic applications. Nanoparticles offer unique physical properties that have associated benefits for drug delivery. These are predominantly due to the particle size (which affects bioavailability and circulation time), large surface area to volume ratio (enhanced solubility compared to larger particles), tunable surface charge of the particle with the possibility of encapsulation, and large drug payloads that can be accommodated. These properties, which are unlike bulk materials of the same compositions, make nanoparticulate drug delivery systems ideal candidates to explore in order to achieve and/or improve therapeutic effects. This review presents a broad overview of the application of nanosized materials for the treatment of common viral infections. </p>

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          Most cited references 218

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          A study of the nucleation and growth processes in the synthesis of colloidal gold

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            Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid–Liquid system

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              Emergence and pandemic potential of swine-origin H1N1 influenza virus.

              Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. A prime example is the recent emergence of swine-origin H1N1 viruses that have transmitted to and spread among humans, resulting in outbreaks internationally. Efforts to control these outbreaks and real-time monitoring of the evolution of this virus should provide us with invaluable information to direct infectious disease control programmes and to improve understanding of the factors that determine viral pathogenicity and/or transmissibility.
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                Author and article information

                Journal
                Therapeutic Advances in Infectious Disease
                Therapeutic Advances in Infection
                SAGE Publications
                2049-9361
                2049-937X
                July 05 2017
                July 2017
                July 05 2017
                July 2017
                : 4
                : 4
                : 105-131
                Affiliations
                [1 ]Department of Virology, National Health Laboratory Service, University of KwaZulu-Natal, Durban, South Africa
                [2 ]Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, South Africa
                Article
                10.1177/2049936117713593
                5507392
                28748089
                © 2017

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