Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche.

Cooper, Denise R; Murr, Michel M.; Patel, Niketa A; El Bassit, Ghattas; Carter, Gay; Patel, Rekha S; Patel, Achintya A.

doi:10.3978/j.issn.2306-9759.2016.01.02

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Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche.

Author(s): Rekha S Patel ¹ , Gay Carter ¹ , Ghattas El Bassit ¹ , Achintya A Patel ¹ , Denise R Cooper ¹ , Michel Murr ¹ , Niketa A Patel ¹

Publication date (Electronic): 2016

Journal: Stem cell investigation

Keywords: Adipose-derived stem cells (ASCs), Protein kinase C delta (PKCδ), adipose stem cell markers, exosome, long noncoding RNAs (lncRNA), obesity, senescence

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Abstract

Adipose-derived stem cells (ASC) and its exosomes are gaining utmost importance in the field of regenerative medicine. The ASCs tested for their potential in wound healing are predominantly derived from the subcutaneous depot of lean donors. However, it is important to characterize the ASC derived from different adipose depots as these depots have clinically distinct roles.

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Journal ID (iso-abbrev): Stem Cell Investig

Title: Stem cell investigation

ISSN: 2306-9759

ISSN (Print): 2306-9759

Publication date (Electronic): 2016

Volume: 3

Affiliations

[1 ] 1 Department of Molecular Medicine, University of South Florida, Tampa, FL, USA ; 2 James A. Haley Veterans Hospital, Tampa, FL, USA ; 3 Honors College, University of South Florida, Tampa, FL, USA ; 4 Department of Surgery, University of South Florida, Tampa, FL, USA.

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Publisher Item ID: sci-03-2016.01.02

DOI: 10.3978/j.issn.2306-9759.2016.01.02

PMC ID: 4923648

PubMed ID: 27358894

SO-VID: 0b89d988-c8cc-427d-b811-f91391c823b2

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Keywords: obesity,senescence,Adipose-derived stem cells (ASCs),Protein kinase C delta (PKCδ),adipose stem cell markers,exosome,long noncoding RNAs (lncRNA)

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Keywords: obesity, senescence, Adipose-derived stem cells (ASCs), Protein kinase C delta (PKCδ), adipose stem cell markers, exosome, long noncoding RNAs (lncRNA)

Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche.

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