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      The Effect of Calcium Infusion on Renal Handling of Magnesium with Normal and Reduced Glomerular Filtration Rate

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      Nephron

      S. Karger AG

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          Abstract

          The effect of calcium chloride infusion on the renal handling of magnesium was evaluated in thyroparathyroidectomized dogs during normal and acute reduction in glomerular filtration rate. The results show that calcium infusion increased urinary magnesium even when the filtered load of magnesium was markedly reduced. The augmented magnesium excretion was associated with an absolute increase in calcium reabsorption. These observations indicate that calcium infusion reduces the tubular reabsorption of magnesium and is consistent with the concept that these two ions share and compete for a common reabsorptive pathway in the nephron. Sodium excretion also increased during chloride infusion but a comparison of the clearances of magnesium (C<sub>Mg</sub>), sodium (C<sub>Na</sub>) and calcium (C<sub>Ca</sub>) indicates that C<sub>Mg</sub> was more closely related to C<sub>Ca</sub> than C<sub>Na</sub> when calcium chloride was infused alone. With the addition of saline infusion, C<sub>Mg</sub> became more dependent on C<sub>Na</sub>

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1970
          1970
          26 November 2008
          : 7
          : 2
          : 131-143
          Affiliations
          Research and Medical Services, Veterans Administration Center, Cedars-Sinai Medical Research Institute, and Departments of Medicine, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA
          Article
          179815 Nephron 1970;7:131–143
          10.1159/000179815
          5438900
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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