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      Evidence for Prolactin Feedback Actions on Hypothalamic Oxytocin, Vasoactive Intestinal Peptide and Dopamine Secretion


      S. Karger AG

      DA, DOPA, Pituitary portal blood, Hypothalamic cell culture, PRL, OT, VIP

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          Ovariectomized rats, when transplanted with 4 anterior pituitaries (APs) to the kidney capsule for 2–3 weeks, had elevated plasma prolactin (PRL) levels (3.8-fold) and showed decreased in situ AP weights (0.62-fold) and PRL concentrations (0.63-fold). The concentrations of dopamine (DA) and oxytocin (OT) in pituitary portal plasma of hyperprolactinemic rats were increased 1.7- and 1.9-fold, respectively. However, the levels of vasoactive intestinal peptide (VIP) in pituitary portal plasma of these rats were decreased 0.31-fold. The secretion of DA, dihydroxyphenylalanine (DOPA) and OT from fetal hypothalamic cells in primary culture was increased, whereas VIP secretion from these cells was reduced in a dose-dependent fashion following PRL treatment. These data are the first in vivo and in vitro demonstration of a stimulatory action of PRL on OT release and an inhibitory action of PRL on VIP release. Furthermore, these data suggest that a subtle imbalance between the secretion of the PRL-inhibiting factor (DA) and the PRL-releasing factors (VIP and OT) during elevated systemic levels of PRL is responsible for decreased lactotrophic function.

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          Author and article information

          S. Karger AG
          02 April 2008
          : 49
          : 5
          : 520-524
          Department of Reproductive Medicine, M-025, University of California at San Diego, La Jolla, Calif., USA
          125161 Neuroendocrinology 1989;49:520–524
          © 1989 S. Karger AG, Basel

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          Pages: 5
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