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      Qualidade de vida em mulheres com neoplasias de mama em quimioterapia Translated title: Quality of life in women with breast cancer undergoing chemotherapy


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          ObjetivoConhecer a qualidade de vida relacionada à saúde de mulheres com câncer de mama em tratamento quimioterápico.MétodosEstudo transversal realizado em instituição especializada, não qual foram incluídas 145 mulheres. Foram utilizados dois questionários padronizados de qualidade relacionada à saúde, traduzidos e validados para a lingua portuguêsa. Utilizou-se o Manual dos Escores da EORTC para calcular os escores dos domínios dos questionários.ResultadosSegundo o primeiro questionário, a função mais afetada foi a emocional. O tratamento provoca dificuldade financeira na maioria das pacientes (média = 41,83). Os sintomas com os maiores escores foram Insônia (37,93), Fadiga (36,01) e Perda de apetite (33,56). Segundo o instrumento Quality of Life Questionnaire - Breast Cancer 23, o escore Efeitos Colaterais teve média de 50,07, significando que muitas mulheres apresentam efeitos colaterais da quimioterapia e satisfação sexual prejudicada.ConclusãoMulheres com câncer de mama apresentaram alterações nos domínios emocional, financeiro, de satisfação sexual e nas perspectivas futuras. Os sintomas mais mencionados foram fadiga, insônia e perda de apetite.

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          ObjectiveThis study aimed to assess the health-related quality of life of women with breast cancer undergoing chemotherapy.MethodsA cross-sectional study carried out in a specialized institution, comprising 145 women. Two standardized questionnaires for health-related quality translated and validated for the Portuguese language were used. The scores manual of the EORTC was used to calculate the domain scores of the questionnaires.ResultsAccording to the first questionnaire, the emotional function was the most affected. The treatment causes financial difficulties for most patients (mean = 41.83). The symptoms with the highest scores were Insomnia (37.93), Fatigue (36.01) and Loss of Appetite (33.56). According to the Quality of Life Questionnaire − Breast Cancer 23, the mean score for Side effects was 50.07, meaning that many women experience side effects of chemotherapy, and impaired sexual satisfaction.ConclusionWomen with breast cancer showed changes in the following domains: financial, emotional, sexual satisfaction and future prospects. The most frequently mentioned symptoms were fatigue, insomnia and loss of appetite.

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          Objective cancer-related variables are not associated with depressive symptoms in women treated for early-stage breast cancer.

          Women with breast cancer are thought to be vulnerable to depression for reasons associated with impact of diagnosis, treatment, and metabolic/endocrine changes. While the literature shows that most of these women do not become clinically depressed, 15% to 30% report elevated depressive symptoms that may be clinically important. The purpose was to identify and determine the relative importance of predictors of depressive symptoms in women treated for early-stage breast cancer. A total of 2,595 women (< or = 4 years following completion of initial treatment for early-stage breast cancer) provided data on cancer-related variables, personal characteristics, health behaviors, physical functioning/symptoms, and psychosocial variables. Participants were divided into high or low depressive groups using the Center for Epidemiologic Studies Depression Scale screening form. Results of the binary logistic regression analysis were significant (overall R2 = 32.4%). Before entry of psychosocial variables, younger age, being unmarried, poorer physical functioning, and more vasomotor and gastrointestinal symptoms were significant risk factors for elevated depressive symptoms (R2 = 16.1%), but objective cancer-related variables were not. After inclusion of psychosocial variables in the model (DeltaR2 = 16.3%), none of the preceding variables remained significant. Greater risk for depressive symptoms was associated with stressful life events, less optimism, ambivalence over expressing negative emotions, sleep disturbance, and poorer social functioning. Depressive symptoms in women treated for early-stage breast cancer are not associated with objective cancer-related factors. Rather, they are most strongly linked with many subjective psychosocial variables.
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              Change in quality of life in Chinese women with breast cancer: changes in psychological distress as a predictor.

              The effect of fluctuating psychological distress on quality of life (QoL) scores is not well delineated. We examined how changes in psychological distress affected change in QoL over time in 259 Chinese women recovering from breast cancer (BC). Women were interviewed during their first postoperative outpatient visit for chemotherapy (Baseline), at 3 months (FU1), and at 6 months after Baseline (FU2). Respondents completed the Chinese version of the FACT-G version-3 scale [FACT-G (Ch)]. Psychological distress was assessed using three categorical measures of depression, mood, and boredom. Linear mixed effects (LME) models examined whether changes in psychological distress predicted subsequent changes in QoL. Respondents' mood improved significantly over time from baseline to FU2 (Baseline/FU2: standardized beta = -0.266, p < 0.005; FU1/FU2: standardized beta = -0.243, p < 0.005). Changes in depression scores consistently predicted subsequent changes in overall (standardized beta = 4.96; 95% CI, 3.749, 6.171, p < 0.001), physical (standardized beta = 1.752; 95% CI, 1.209, 2.294, p < 0.001), and functional (standardized beta = 0.872; 95% CI, 0.308, 1.436, p < 0.001) QoL scores. The magnitude of change in psychological distress significantly impacted physical and functional, but not social QoL in Chinese BC patients. These data highlight the need to address psychological and physical distress as part of the drive to improve physical and functional QoL for women with BC.

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                Acta Paulista de Enfermagem
                Acta paul. enferm.
                Escola Paulista de Enfermagem, Universidade Federal de São Paulo (São Paulo )
                December 2014
                : 27
                : 6
                : 554-559
                [1 ] Universidade Federal do Ceará Brazil
                [2 ] Universidade Estadual do Ceará Brazil
                [3 ] Universidade da Integração Internacional da Lusofonia Afro-Brasileira Brazil
                [4 ] Universidade de São Paulo Brazil
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