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      Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

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          Abstract

          The field of medical micro/nanorobotics holds considerable promise for advancing medical diagnosis and treatment due to their unique ability to move and perform complex task at small scales. Nevertheless, the grand challenge of the field remains in its successful translation towards widespread patient use. We critically address the frontiers of the current methodologies for in vivo applications and discuss the current and foreseeable perspectives of their commercialization. Although no “killer application” that would catalyze rapid commercialization has yet emerged, recent engineering breakthroughs have led to the successful in vivo operation of medical micro/nanorobots. We also highlight how standardizing report summaries of micro/nanorobotics is essential not only for increasing the quality of research but also for minimizing investment risk in their potential commercialization. We review current patents and commercialization efforts based on emerging proof-of-concept applications. We expect to inspire future research efforts in the field of micro/nanorobotics toward future medical diagnosis and treatment.

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          Most cited references62

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          Microrobots for minimally invasive medicine.

          Microrobots have the potential to revolutionize many aspects of medicine. These untethered, wirelessly controlled and powered devices will make existing therapeutic and diagnostic procedures less invasive and will enable new procedures never before possible. The aim of this review is threefold: first, to provide a comprehensive survey of the technological state of the art in medical microrobots; second, to explore the potential impact of medical microrobots and inspire future research in this field; and third, to provide a collection of valuable information and engineering tools for the design of medical microrobots.
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            Micro/nanorobots for biomedicine: Delivery, surgery, sensing, and detoxification

            Micro- and nanoscale robots that can effectively convert diverse energy sources into movement and force represent a rapidly emerging and fascinating robotics research area. Recent advances in the design, fabrication, and operation of micro/nanorobots have greatly enhanced their power, function, and versatility. The new capabilities of these tiny untethered machines indicate immense potential for a variety of biomedical applications. This article reviews recent progress and future perspectives of micro/nanorobots in biomedicine, with a special focus on their potential advantages and applications for directed drug delivery, precision surgery, medical diagnosis and detoxification. Future success of this technology, to be realized through close collaboration between robotics, medical and nanotechnology experts, should have a major impact on disease diagnosis, treatment, and prevention.
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              Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

              Oxygen depleted hypoxic regions in the tumour are generally resistant to therapies 1 . Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour 2 of magnetotactic bacteria 3 , Magnetococcus marinus strain MC-1 4 , can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals 5 , tend to swim along local magnetic field lines and towards low oxygen concentrations 6 based on a two-state aerotactic sensing system 2 . We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in SCID Beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
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                Author and article information

                Contributors
                Journal
                Front Bioeng Biotechnol
                Front Bioeng Biotechnol
                Front. Bioeng. Biotechnol.
                Frontiers in Bioengineering and Biotechnology
                Frontiers Media S.A.
                2296-4185
                14 November 2018
                2018
                : 6
                : 170
                Affiliations
                [1] 1Department of Nanoengineering, University of California, San Diego , La Jolla, CA, United States
                [2] 2Texas Materials Institute, The University of Texas at Austin , Austin, TX, United States
                Author notes

                Edited by: Gianni Ciofani, Politecnico di Torino, Italy

                Reviewed by: Arianna Menciassi, Scuola Sant'Anna di Studi Avanzati, Italy; Edoardo Sinibaldi, Fondazione Istituto Italiano di Technologia, Italy

                *Correspondence: Fernando Soto f1soto@ 123456ucsd.edu

                This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology

                Article
                10.3389/fbioe.2018.00170
                6246686
                30488033
                0bb2bd80-5faa-41fa-9aa2-0f34f5ff6397
                Copyright © 2018 Soto and Chrostowski.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 29 August 2018
                : 25 October 2018
                Page count
                Figures: 6, Tables: 1, Equations: 0, References: 120, Pages: 12, Words: 8939
                Categories
                Bioengineering and Biotechnology
                Review

                nanomedicine,medical translational research,in vivo,commercialization,microrobot,nanorobot

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