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      Renal Involvement in Feline Immunodeficiency Virus Infection: A Clinicopathological Study

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          Abstract

          Renal tissues from 15 cats naturally infected with feline immunodeficiency virus (FIV) were examined histologically, immunohistochemically and ultrastructurally. Renal function and urinary proteins were also studied. Kidney abnormalities were found in 12 cats and were characterized by mesangial widening with segmental to diffuse glomerulosclerosis and presence of IgM and C3, and scanty IgG deposits in the mesangium. Tubulointerstitial lesions were also present. In 6 cats the lesions were severe enough to cause marked increase in blood urea nitrogen and creatinine, and heavy glomerular nonselective proteinuria. These findings suggest that a renal involvement is a frequent occurrence in FIV-infected cats. As the histopathological features observed were similar to those described in HIV-infected patients, FIV-infected cats may represent a valuable model for a better understanding of HIV-associated nephropathy in humans.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1993
          1993
          12 December 2008
          : 64
          : 2
          : 282-288
          Affiliations
          aDipartimento di Patologia Animate, Profilassi ed Igiene degli Alimenti, and bIstituto di Patologia Speciale e Clinica Medica Veterinaria, Università di Pisa; cDipartimento di Biopatologia Umana, Università ‘La Sapienza’ di Roma; dDipartimento di Biomedicina, Università di Pisa, Italy.
          Article
          187327 Nephron 1993;64:282–288
          10.1159/000187327
          8321363
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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