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      Abolition of the Effect of Pinealectomy on Hypothalamic Magnocellular Neurosecretory Activity in Male Rats by Hypothalamic Pineal Implants

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          Abstract

          Neurosecretory activity of the hypothalamic magnocellular supraoptic nucleus (SON) was determined in male rats after pinealectomy, sham-operation, and pinealectomy followed by unilateral implantation into the hypothalamus of either pineal glandular tissue or cerebellar tissue from littermate donor rats. The distribution of thiamine diphosphate-phosphohydrolase (TPP-ase), a Golgi apparatus-specific enzyme, was measured with a Zeiss Hennig ocular and used as a parameter for neurosecretory activity. Both SON’s of sham-operated rats receiving both types of implants exhibited no reaction at all. In pinealectomized rats receiving cerebellar implants, however, both SON’s showed decreased activity. On the other hand, in pinealectomized rats receiving unilateral pineal implants, normal control values were found on the homolateral side, while on the heterolateral side the same decreased activity found in the cerebellar-implant group was observed. This finding points to a direct action of the pineal gland on the SON, especially in view of the decreased activity seen in rats bearing pineal implants situated at a greater distance from the SON.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1972
          1972
          19 March 2008
          : 9
          : 6
          : 358-364
          Affiliations
          Netherlands Central Institute for Brain Research, Amsterdam
          Article
          122068 Neuroendocrinology 1972;9:358–364
          10.1159/000122068
          5037210
          0bcec70b-bcff-4792-b586-22df47ef035c
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 10 November 1971
          : 07 February 1972
          Page count
          Pages: 7
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Pineal gland,Hypothalamic magnocellular neurosecretion,Pinealectomy,Thiamine diphosphate-phosphohydrolase (TPP-ase),Supraoptic nucleus

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