Clozapine-Induced Effuso-Constrictive Pericarditis

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Abstract

Clozapine is a widely used antipsychotic medication and is effective against both positive and negative symptoms of schizophrenia. However, clozapine use should be monitored closely due to its side effects profile. The main side effects include cardiorespiratory symptoms, seizures and agranulocytosis. We report a case of effuso-constrictive pericarditis soon after being started on clozapine therapy, whose symptoms improved after discontinuation of clozapine. The literature is reviewed and importance of monitoring is discussed.

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Most cited references 2

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Clozapine rechallenge after myocarditis.

P. Reid, M McArthur, S Pridmore (2001)

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ST segment elevations without myocardial infarction in a patient on clozapine

James Ketch, Anthony Herd, Louis Ludwig (1996)

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 2007

Publication date (Print): September 2007

Publication date (Electronic): 02 November 2006

Volume: 108

Issue: 3

Pages: 183-185

Affiliations

^aThe Cardiothoracic Centre, Liverpool, and ^bUniversity Hospital of Wales, Cardiff, UK

Article

Publisher ID: 96666 Other ID: Cardiology 2007;108:183–185

DOI: 10.1159/000096666

PubMed ID: 17085936

SO-VID: 0c07d033-b865-4e03-9307-a1a034ed9d2d

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 07 July 2006

Date accepted : 24 July 2006

Page count

Figures: 2, References: 8, Pages: 3

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