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      Maggot Therapy Takes Us Back to the Future of Wound Care: New and Improved Maggot Therapy for the 21st Century

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      Journal of Diabetes Science and Technology
      SAGE Publications

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          Abstract

          In the 21st century, eighty years after William Baer presented his groundbreaking work treating bone and soft tissue infections with live maggots, thousands of therapists around the globe have rediscovered the benefits of maggot therapy. The renaissance in maggot therapy is due in large part to recent technological advancements that have solved or minimized many of the treatment's earlier drawbacks: the need for reliable access to this perishable medical device, simplified application, and low-cost production. Modern dressing materials have simplified the procedure and minimized the risk of escaping maggots. The establishment of dozens of laboratories throughout the world, along with access to overnight courier services in many regions, has made medicinal maggots readily available to millions of people in need. Studies show that fears of patient nonacceptance are unfounded. The medical literature is rapidly growing with scientific evidence demonstrating the efficacy and safety of maggot therapy for a variety of problematic wounds. This article examines how these and other technologies are optimizing the study and application of maggot therapy for wound care. (c) 2009 Diabetes Technology Society.

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          Most cited references67

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          Medicinal maggots: an ancient remedy for some contemporary afflictions.

          Certain fly larvae can infest corpses or the wounds of live hosts. Those which are least invasive on live hosts have been used therapeutically, to remove dead tissue from wounds, and promote healing. This medicinal use of maggots is increasing around the world, due to its efficacy, safety and simplicity. Given our low cultural esteem for maggots, the increasing use and popularity of maggot therapy is evidence of its utility. Maggot therapy has successfully treated many types of chronic wounds, but much clinical and basic research is needed still. In this review, the biology of myiasis and the history of maggot therapy are presented, the current status of our understanding and clinical use of medicinal maggots is discussed, and opportunities for future research and applications are proposed.
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            Science, medicine, and the future: Healing chronic wounds

            K Harding (2002)
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              Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy.

              To assess the efficacy of maggot therapy for treating foot and leg ulcers in diabetic patients failing conventional therapy. Retrospective comparison of changes in necrotic and total surface area of chronic wounds treated with either maggot therapy or standard (control) surgical or nonsurgical therapy. In this cohort of 18 patients with 20 nonhealing ulcers, six wounds were treated with conventional therapy, six with maggot therapy, and eight with conventional therapy first, then maggot therapy. Repeated measures ANOVA indicated no significant change in necrotic tissue, except when factoring for treatment (F [1.7, 34] = 5.27, P = 0.013). During the first 14 days of conventional therapy, there was no significant debridement of necrotic tissue; during the same period with maggot therapy, necrotic tissue decreased by an average of 4.1 cm(2) (P = 0.02). After 5 weeks of therapy, conventionally treated wounds were still covered with necrotic tissue over 33% of their surface, whereas after only 4 weeks of therapy maggot-treated wounds were completely debrided (P = 0.001). Maggot therapy was also associated with hastened growth of granulation tissue and greater wound healing rates. Maggot therapy was more effective and efficient in debriding nonhealing foot and leg ulcers in male diabetic veterans than was continued conventional care.
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                Author and article information

                Journal
                Journal of Diabetes Science and Technology
                J Diabetes Sci Technol
                SAGE Publications
                1932-2968
                1932-2968
                March 2009
                March 2009
                March 2009
                March 2009
                : 3
                : 2
                : 336-344
                Affiliations
                [1 ]BioTherapeutics, Education and Research Foundation, Irvine, California; Special Diseases Branch, Orange County Health Care Agency, Santa Ana, California; and Monarch Labs, LLC, Irvine, California
                Article
                10.1177/193229680900300215
                2771513
                20144365
                0c165e6f-ff00-4775-a722-e4f51d8ec21a
                © 2009

                http://journals.sagepub.com/page/policies/text-and-data-mining-license

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