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      Renal Handling of Beta-2-Microglobulin in Renal Disorders; with Special Reference to Hepatorenal Syndrome

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          Abstract

          A study of serum β<sub>2</sub>-microglobulin and urinary β<sub>2</sub>-microglobulin in patients with liver and/or kidney disease was done to determine if such information is of diagnostic help. Serum concentrations and β<sub>2</sub>M/Cr clearance ratios are higher in patients with primary tubular disorders than in those with glomerular diseases, a finding unaltered by hepatic disease. These data suggest either an increased production or decreased tubular degradation of β<sub>2</sub>M, independent of the glomerular filtration rate (GFR), in primary tubular disorders. The marked increase in urinary β<sub>2</sub>-microglobulin that followed insertion of the peritoneal-jugular shunt is evidence that this procedure resulted in improvement of the GFR, in previously underperfused nephrons.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          02 December 2008
          : 27
          : 2
          : 62-66
          Affiliations
          Division of Nephrology, Case Western Reserve University at Cleveland Metropolitan General Hospital, Cleveland, Ohio
          Article
          182026 Nephron 1981;27:62–66
          10.1159/000182026
          6167871
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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