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      Renal Handling of Beta-2-Microglobulin in Renal Disorders; with Special Reference to Hepatorenal Syndrome

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          Abstract

          A study of serum β<sub>2</sub>-microglobulin and urinary β<sub>2</sub>-microglobulin in patients with liver and/or kidney disease was done to determine if such information is of diagnostic help. Serum concentrations and β<sub>2</sub>M/Cr clearance ratios are higher in patients with primary tubular disorders than in those with glomerular diseases, a finding unaltered by hepatic disease. These data suggest either an increased production or decreased tubular degradation of β<sub>2</sub>M, independent of the glomerular filtration rate (GFR), in primary tubular disorders. The marked increase in urinary β<sub>2</sub>-microglobulin that followed insertion of the peritoneal-jugular shunt is evidence that this procedure resulted in improvement of the GFR, in previously underperfused nephrons.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          02 December 2008
          : 27
          : 2
          : 62-66
          Affiliations
          Division of Nephrology, Case Western Reserve University at Cleveland Metropolitan General Hospital, Cleveland, Ohio
          Article
          182026 Nephron 1981;27:62–66
          10.1159/000182026
          6167871
          0c1a63cd-5229-4c1a-bb93-0b0792b13025
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 30 April 1980
          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          &beta;2-Microglobulin,Urinary clearance ratio of &beta;2-microglobulin to creatinine,Hepatorenal syndrome,Tubular proteinuria

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