Blog
About

28
views
0
recommends
+1 Recommend
1 collections
    19
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity.

      Learning & memory (Cold Spring Harbor, N.Y.)

      Analysis of Variance, Brain Mapping, CA1 Region, Hippocampal, blood supply, physiology, CA3 Region, Hippocampal, Dentate Gyrus, Discrimination (Psychology), Hippocampus, anatomy & histology, Humans, Image Processing, Computer-Assisted, methods, Magnetic Resonance Imaging, Memory, Oxygen, blood, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Transfer (Psychology)

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Producing and maintaining distinct (orthogonal) neural representations for similar events is critical to avoiding interference in long-term memory. Recently, our laboratory provided the first evidence for separation-like signals in the human CA3/dentate. Here, we extended this by parametrically varying the change in input (similarity) while monitoring CA1 and CA3/dentate for separation and completion-like signals using high-resolution fMRI. In the CA1, activity varied in a graded fashion in response to increases in the change in input. In contrast, the CA3/dentate showed a stepwise transfer function that was highly sensitive to small changes in input.

          Related collections

          Author and article information

          Journal
          21164173
          3023966
          10.1101/lm.1971111

          Comments

          Comment on this article