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      Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity.

      Learning & memory (Cold Spring Harbor, N.Y.)
      Analysis of Variance, Brain Mapping, CA1 Region, Hippocampal, blood supply, physiology, CA3 Region, Hippocampal, Dentate Gyrus, Discrimination (Psychology), Hippocampus, anatomy & histology, Humans, Image Processing, Computer-Assisted, methods, Magnetic Resonance Imaging, Memory, Oxygen, blood, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Transfer (Psychology)

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          Producing and maintaining distinct (orthogonal) neural representations for similar events is critical to avoiding interference in long-term memory. Recently, our laboratory provided the first evidence for separation-like signals in the human CA3/dentate. Here, we extended this by parametrically varying the change in input (similarity) while monitoring CA1 and CA3/dentate for separation and completion-like signals using high-resolution fMRI. In the CA1, activity varied in a graded fashion in response to increases in the change in input. In contrast, the CA3/dentate showed a stepwise transfer function that was highly sensitive to small changes in input.

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