This study replicates the alleviation of jet-lag with melatonin in a simplified protocol
for eastward flight. At 22-n hr (n is the time-lag between the North American departure
point and France), subjects took either melatonin (8 mg, n = 15), or placebo (n =
15) on the day of the return flight and for 3 consecutive days. On day 8, self-ratings
significantly discriminated between melatonin and placebo for global treatment efficacy,
morning fatigue, and evening sleepiness.