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      Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds.

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          Abstract

          There is an unmet clinical need for wound dressings to treat partial thickness burns that damage the epidermis and dermis. An ideal dressing needs to prevent infection, maintain skin hydration to facilitate debridement of the necrotic tissue, and provide cues to enhance tissue regeneration. We developed a class of 'smart' peptide hydrogels, which fulfill these criteria. Our ultrashort aliphatic peptides have an innate tendency to self-assemble into helical fibers, forming biomimetic hydrogel scaffolds which are non-immunogenic and non-cytotoxic. These nanofibrous hydrogels accelerated wound closure in a rat model for partial thickness burns. Two peptide hydrogel candidates demonstrate earlier onset and completion of autolytic debridement, compared to Mepitel(®), a silicone-coated polyamide net used as standard-of-care. They also promote epithelial and dermal regeneration in the absence of exogenous growth factors, achieving 86.2% and 92.9% wound closure respectively, after 14 days. In comparison, only 62.8% of the burnt area is healed for wounds dressed with Mepitel(®). Since the rate of wound closure is inversely correlated with hypertrophic scar formation and infection risks, our peptide hydrogel technology fills a niche neglected by current treatment options. The regenerative properties can be further enhanced by incorporation of bioactive moieties such as growth factors and cytokines.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          1878-5905
          0142-9612
          Jun 2014
          : 35
          : 17
          Affiliations
          [1 ] Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore.
          [2 ] Combat Care and Performance Laboratory, Defence Medical Research Institute, DSO National Laboratories, 27 Medical Drive #12-01, Singapore 117510, Singapore.
          [3 ] Department of Surgery (Division of Plastic, Aesthetic and Reconstructive Surgery), Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 8, 1E Kent Ridge Road, Singapore 119228, Singapore.
          [4 ] Biostatistic Unit, Dean's Office, Level 1, Block MD11, 10 Medical Drive, Singapore 117597, Singapore.
          [5 ] Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore. Electronic address: chauser@ibn.a-star.edu.sg.
          Article
          S0142-9612(14)00203-8
          10.1016/j.biomaterials.2014.02.047
          24636214
          Copyright © 2014 Elsevier Ltd. All rights reserved.

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