Blog
About


  • Record: found
  • Abstract: found
  • Article: not found

Rumen epithelial cell proliferation accelerated by rapid increase in intraruminal butyrate.

Journal of dairy science

Time Factors, anatomy & histology, Sheep, drug effects, cytology, Rumen, Mitosis, Male, Epithelium, Epithelial Cells, administration & dosage, Butyrates, Animals

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Two pairs of adult castrated male sheep were given intraruminally 2 g/kg body weight per day of sodium n-butyrate rapidly 10 s at noon or slowly over 20 to 24 h from noon in four trials in which they received only mixed minerals and water ad libitum. Their ruminal papillae were biopsied just before each administration and 24 h after the final administration. Mitotic indices of the epithelial cells were observed. Mitotic indices were lower than .48% before butyrate administration. In sheep rapidly administered butyrate, mitotic indices increased to 1.29%, 2.33%, 2.65%, and 1.84% in 1 day after the first administration in four trials and tended to decline on later days. In sheep slowly administered butyrate, mitotic indices stayed lower than .50% and did not show significant fluctuations. Our data support our hypothesis that an increase in the rate of intraruminal production of volatile fatty acids promotes proliferation of epithelial cells of the organ.

      Related collections

      Author and article information

      Journal
      10.3168/jds.S0022-0302(78)83694-7
      721981
      ScienceOpen disciplines:
      Keywords:

      Comments

      Comment on this article

      Register to benefit from advanced discovery features on more than 41,000,000 articles

      Already registered?

      Email*:
      Password*: