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      An Efficient hybrid filter-wrapper metaheuristic-based gene selection method for high dimensional datasets

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          Abstract

          Feature selection problem is one of the most significant issues in data classification. The purpose of feature selection is selection of the least number of features in order to increase accuracy and decrease the cost of data classification. In recent years, due to appearance of high-dimensional datasets with low number of samples, classification models have encountered over-fitting problem. Therefore, the need for feature selection methods that are used to remove the extensions and irrelevant features is felt. Recently, although, various methods have been proposed for selecting the optimal subset of features with high precision, these methods have encountered some problems such as instability, high convergence time, selection of a semi-optimal solution as the final result. In other words, they have not been able to fully extract the effective features. In this paper, a hybrid method based on the IWSSr method and Shuffled Frog Leaping Algorithm (SFLA) is proposed to select effective features in a large-scale gene dataset. The proposed algorithm is implemented in two phases: filtering and wrapping. In the filter phase, the Relief method is used for weighting features. Then, in the wrapping phase, by using the SFLA and the IWSSr algorithms, the search for effective features in a feature-rich area is performed. The proposed method is evaluated by using some standard gene expression datasets. The experimental results approve that the proposed approach in comparison to similar methods, has been achieved a more compact set of features along with high accuracy. The source code and testing datasets are available at https://github.com/jimy2020/SFLA_IWSSr-Feature-Selection.

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          Most cited references42

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          Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

          T. Golub (1999)
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            Prediction of central nervous system embryonal tumour outcome based on gene expression.

            Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of childhood, but their pathogenesis is unknown, their relationship to other embryonal CNS tumours is debated, and patients' response to therapy is difficult to predict. We approached these problems by developing a classification system based on DNA microarray gene expression data derived from 99 patient samples. Here we demonstrate that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours (PNETs), atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas. Previously unrecognized evidence supporting the derivation of medulloblastomas from cerebellar granule cells through activation of the Sonic Hedgehog (SHH) pathway was also revealed. We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis.
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              MINIMUM REDUNDANCY FEATURE SELECTION FROM MICROARRAY GENE EXPRESSION DATA

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                Author and article information

                Contributors
                j.pirgazi@znu.ac.ir
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                9 December 2019
                9 December 2019
                2019
                : 9
                : 18580
                Affiliations
                [1 ]Faculty of Engineering, Department of Computer Engineering, University of Gonabad, Gonabad, Iran
                [2 ]ISNI 0000 0004 0417 6900, GRID grid.449392.1, Faculty of Electronic, Computer & IT Department of Computer, , Qazvin Islamic Azad University, ; Qazvin, Iran
                Author information
                http://orcid.org/0000-0002-2461-1143
                Article
                54987
                10.1038/s41598-019-54987-1
                6901457
                31819106
                0c7ef307-8b2a-400d-9724-d3bdcd40479d
                © The Author(s) 2019

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 5 September 2019
                : 22 November 2019
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                © The Author(s) 2019

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                machine learning,microarrays
                Uncategorized
                machine learning, microarrays

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