Evaluation of the Cytosorb™ Hemoadsorptive Column in a Pig Model of Severe Smoke and Burn Injury.

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Abstract

Host inflammatory response to any form of tissue injury, including burn, trauma, or shock, has been well documented. After significant burns, cytokines can increase substantially within the first 24 h after injury and may contribute to subsequent organ failure. Hemoadsorption by cytokine-adsorbing columns may attenuate this maladaptive response, thereby improving outcomes. The aim of this study was to investigate the feasibility, technical safety, and efficacy of cytokine and myoglobin removal by early use of a cytokine absorbing column (CytoSorb) in a porcine model of smoke inhalation and burn injury.

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Journal

Journal ID (iso-abbrev): Shock

Title: Shock (Augusta, Ga.)

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1540-0514

ISSN (Print): 1073-2322

Publication date (Electronic): Nov 2015

Volume: 44

Issue: 5

Affiliations

[1 ] *United States Army Institute of Surgical Research, Fort Sam Houston, Houston, Texas †University of Texas Health Science Center at San Antonio ‡San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas §Pediatric Cardiology Department, University Hospital Bonn, Bonn, Germany ¶Dipartimento di Scienze della Salute, Università degli Studi di Milano-Bicocca, Monza, Italy ||Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Article

DOI: 10.1097/SHK.0000000000000439

PubMed ID: 26368927

SO-VID: 0c85957b-45a1-47a5-aba3-6766a77d1891

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