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      Effects of Active and Passive Wall Stress Changes on the Rhythmic Mechanical Activity of the Pressurized Rat Tail Artery


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          Rhythmic mechanical activity was recorded in vitro in isolated rat tail arteries. Pressurized cylindrical segments of this artery, stretched to their in situ length, exhibit well-synchronized rhythmic contractions. Frequency and amplitude of the rhythmic activity can be modified by (1) passive stretch at a given constrictor agonist concentration, as well as by (2) active wall stress changes induced by varying doses of constrictor agonists. At a norepinephrine concentration of 0.5 µ M, the frequency (f) of rhythmic contractions increases from 0.2 to 0.65 [sec<sup>–1</sup>], when the mean circumferential wall stress (σ) is increased from 1 · 10<sup>5</sup> to 1 · 10<sup>6</sup> dyn/cm<sup>2</sup>. The relationship between f and σ is, at a constant smooth muscle tone, virtually independent of the rate and also of the direction of the applied stress changes. Changes of the smooth muscle tone (i.e. changes of the actively developed wall stress), induced by vasoactive agents or other stimuli, lead to virtually parallel shifts of the σ-f relationship, which is obtained by passive stretching. It is concluded that the actual stimulus for the stretch-sensing structure in the arterial smooth muscle is the change in wall stress rather than the change in strain. Since rhythmic contractions may still be observed 30–60 min after withdrawal of Ca<sup>++</sup> from the bath solution, extracellular Ca<sup>++</sup> seems not to be primarily involved in this rhythmicity.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 21
          : 5
          : 231-245
          Department of Applied Physiology, University of Freiburg, FRG
          158516 Blood Vessels 1984;21:231–245
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 15 March 1983
          : 23 February 1984
          Page count
          Pages: 15
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Rat tail artery,Pacemaker activity,Circumferential wall stress,Myogenic response,Rhythmic mechanical activity,Arterial smooth muscle


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