An autologous platelet-rich plasma hydrogel compound restores left ventricular structure, function and ameliorates adverse remodeling in a minimally invasive large animal myocardial restoration model: a translational approach: Vu and Pal "Myocardial Repair: PRP, Hydrogel and Supplements".

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Abstract

Cell-based myocardial restoration has not penetrated broad clinical practice yet due to poor cell retention and survival rates. In this study, we attempt a translational, large-scale restorative but minimally invasive approach in the pig, aiming at both structurally stabilizing the left ventricular (LV) wall and enhancing function following ischemic injury.

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Journal

Journal ID (iso-abbrev): Biomaterials

Title: Biomaterials

ISSN (Electronic): 1878-5905

ISSN (Print): 0142-9612

Publication date (Electronic): Mar 2015

Volume: 45

Affiliations

[1 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

[2 ] Department of Anesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

[3 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

[4 ] Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

[5 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore.

[6 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore. Electronic address: surtk@nus.edu.sg.

Article

Publisher Item ID: S0142-9612(14)01257-5

DOI: 10.1016/j.biomaterials.2014.12.013

PubMed ID: 25662492

SO-VID: 0c95792e-1d96-4456-b604-efc5066eb16d

History

Keywords: Antioxidants,Heart failure,Hyaluronic acid-based hydrogels,Left ventricular restoration,Myocardial infarction,Platelet-rich plasma

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Keywords: Antioxidants, Heart failure, Hyaluronic acid-based hydrogels, Left ventricular restoration, Myocardial infarction, Platelet-rich plasma

An autologous platelet-rich plasma hydrogel compound restores left ventricular structure, function and ameliorates adverse remodeling in a minimally invasive large animal myocardial restoration model: a translational approach: Vu and Pal "Myocardial Repair: PRP, Hydrogel and Supplements".

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Karger: Cardiovascular System

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