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      An autologous platelet-rich plasma hydrogel compound restores left ventricular structure, function and ameliorates adverse remodeling in a minimally invasive large animal myocardial restoration model: a translational approach: Vu and Pal "Myocardial Repair: PRP, Hydrogel and Supplements".

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          Abstract

          Cell-based myocardial restoration has not penetrated broad clinical practice yet due to poor cell retention and survival rates. In this study, we attempt a translational, large-scale restorative but minimally invasive approach in the pig, aiming at both structurally stabilizing the left ventricular (LV) wall and enhancing function following ischemic injury.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          1878-5905
          0142-9612
          Mar 2015
          : 45
          Affiliations
          [1 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
          [2 ] Department of Anesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
          [3 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
          [4 ] Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
          [5 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore.
          [6 ] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore. Electronic address: surtk@nus.edu.sg.
          Article
          S0142-9612(14)01257-5
          10.1016/j.biomaterials.2014.12.013
          25662492
          Copyright © 2014 Elsevier Ltd. All rights reserved.

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