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      • Record: found
      • Abstract: found
      • Article: found
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      Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Mycoplasma pneumoniae Infection

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          Abstract

          Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection). Possible synergism between previously known drug allergy and the acute Mycoplasma infection may have led to DRESS eruption. Interferon-γ release test and TNF-α release test yielded different patterns in the present case, suggesting a different role for each in different drug eruption types.

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          Most cited references11

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          Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?

          S Kardaun, A Sidoroff, L Valeyrie-Allanore … (2007)
          Article 0 comments Cited 225 times – based on 0 reviews     Review now
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            Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections.

            Thomas Prescott Atkinson, Mitchell F Balish, Ken B Waites (2008)
            Since its initial description in the 1940s and eventual elucidation as a highly evolved pathogenic bacterium, Mycoplasma pneumoniae has come to be recognized as a worldwide cause of primary atypical pneumonia. Beyond its ability to cause severe lower respiratory illness and milder upper respiratory symptoms it has become apparent that a wide array of extrapulmonary infectious and postinfectious events may accompany the infections in humans caused by this organism. Autoimmune disorders and chronic diseases such as asthma and arthritis are increasingly being associated with this mycoplasma, which frequently persists in individuals for prolonged periods. The reductive evolutionary process that has led to the minimal genome of M. pneumoniae suggests that it exists as a highly specialized parasitic bacterium capable of residing in an intracellular state within the respiratory tissues, occasionally emerging to produce symptoms. This review includes discussion of some of the newer aspects of our knowledge on this pathogen, characteristics of clinical infections, how it causes disease, the recent emergence of macrolide resistance, and the status of laboratory diagnostic methods.
            Article 0 comments Cited 52 times – based on 0 reviews     Review now
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              Drug reaction with eosinophilia and systemic symptoms: is cutaneous phenotype a prognostic marker for outcome? A review of clinicopathological features of 27 cases.

              S. Walsh, S Diaz-Cano, E M Higgins … (2013)
              Drug reaction with eosinophilia and systemic symptoms (DRESS) describes a heterogeneous group of severe adverse reactions to medications. The cutaneous phenotype has a number of guises, accompanied by a variety of systemic features including fever, haematological abnormalities and visceral involvement, most commonly the liver. Clinical markers of prognosis have not been identified.
              Article 0 comments Cited 26 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): CDE
                Journal ID (pmc): CDE
                Journal ID (doi): 10.1159/issn.1662-6567
                Title: Case Reports in Dermatology
                Publisher: S. Karger AG
                ISSN (Electronic): 1662-6567
                Publication date Subscription-year: 2020
                Publication date Collection: September - December 2020
                Publication date (Electronic): 12 November 2020
                Volume: 12
                Issue: 3
                Pages: 225-230
                Affiliations
                [_a] aFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
                [_b] bClalit Health Services, Tel-Aviv, Israel
                [_c] cPediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel
                Author notes
                *Amir Horev, Soroka University Medical Center, PO Box 151, Beer-Sheva 84101 (Israel), amirhor@clalit.org.il
                Author information
                https://orcid.org/0000-0001-6646-9061
                Article
                Publisher ID: 510706 Other ID: Case Rep Dermatol 2020;12:225–230
                DOI: 10.1159/000510706
                PMC ID: 7747052
                SO-VID: 0c991d23-7dc4-4887-a33c-dcdef933d351
                Copyright © © 2020 The Author(s). Published by S. Karger AG, Basel
                License:

                This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 29 April 2020
                Date accepted : 06 August 2020
                Page count
                Figures: 3, Pages: 6
                Categories
                Subject: Single Case

                ScienceOpen disciplines: Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
                Keywords: Interferon-γ release test,Infection,Mycoplasma,Adverse drug reaction,Drug eruption,Drug reaction with eosinophilia and systemic symptoms (DRESS)
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy, Pathology, Surgery, Dermatology, Pharmacology & Pharmaceutical medicine
                Keywords: Interferon-γ release test, Infection, Mycoplasma, Adverse drug reaction, Drug eruption, Drug reaction with eosinophilia and systemic symptoms (DRESS)

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