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      Differential Regulation of Tyrosine Hydroxylase, Neuropeptide Y and Galanin Gene Expression in the Pons and Medulla oblongata following Chronic Oral Administration of 2% Saline: A Combined in situ Hybridisation and Immunohistochemical Study

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          Abstract

          In situ hybridisation histochemistry and immunohistochemistry was used to study the response of the noradrenergic A6 and A2 cell groups in the rat following oral administration of 2% saline for 12 days. Messenger ribonucleic acid (mRNA) encoding tyrosine hydroxylase and neuropeptide Y increased by 85 and 65%, respectively (p < 0.05) in A6, while levels in A2 were unaltered after saline ingestion. The observed changes in mRNA were accompanied by increased expression of neuropeptide Y and tyrosine hydroxylase immunoreactivities in A6 neurons, whereas A2 neurons were unaffected. In contrast, mRNA encoding galanin, which is also colocalised with noradrenaline in A6 cells, was unaltered by osmotic stimulation. Our results suggest that noradrenaline and neuropeptide Y transmitter systems in the A6 group are activated whereas the galanin transmitter system remains unaffected during saline ingestion.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1992
          1992
          07 April 2008
          : 55
          : 5
          : 544-551
          Affiliations
          Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, UK
          Article
          126168 Neuroendocrinology 1992;55:544–551
          10.1159/000126168
          1374851
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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