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      Review of therapeutic options for infections with carbapenem-resistant Klebsiella pneumoniae

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          Abstract

          Infections with multi-drug resistant (MDR) bacteria including carbapenem-resistant Klebsiella pneumoniae are emerging worldwide but are difficult to treat with the currently available antibiotic compounds and therefore constitute serious threats to human health. This prompted us to perform a literature survey applying the MEDLINE database and Cochrane Register of Controlled Trials including clinical trials comparing different treatment regimens for infections caused by carbapenem-resistant K. pneumoniae. Our survey revealed that a combined application of antibiotic compounds such as meropenem plus vaborbactam, meropenem plus colistin and carbapenem plus carbapenem, resulted in significantly increased clinical cure and decreased mortality rates as compared to respective control treatment. However, further research on novel antibiotic compounds, but also on antibiotic-independent molecules providing synergistic or at least resistance-modifying properties needs to be undertaken in vitro as well as in large clinical trials to provide future options in the combat of emerging life-threatening infections caused by MDR bacteria.

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          Author and article information

          Contributors
          Journal
          1886
          European Journal of Microbiology and Immunology
          Akadémiai Kiadó (Budapest )
          2062-8633
          17 September 2020
          Affiliations
          Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charité – University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health , Berlin, Germany
          Author notes
          [ * ]Corresponding author. Department of Microbiology, Infectious Diseases and Immunology, Charité – University Medicine Berlin , CC5, Campus Benjamin Franklin, FEM, Garystr. 5, D-14195, Berlin, Germany. Tel.: +49 30 450524318 markus.heimesaat@ 123456charite.de
          Article
          10.1556/1886.2020.00022
          © 2020 The Authors

          Open Access. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

          Page count
          Tables: 3, Equations: 0, References: 48, Pages: 10
          Product
          Self URI (journal page): https://akademiai.com/loi/1886
          Funding
          Funded by: German Federal Ministries of Education and Research (BMBF)
          Award ID: IP7/01KI1725D
          Funded by: German National Parliament, Deutscher Bundestag
          Award ID: ZF4117908 AJ8
          Categories
          Review Paper

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