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      Anatomical Profiling of G Protein-Coupled Receptor Expression

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      Cell

      Elsevier BV

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          Abstract

          G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane signaling molecules and regulate a host of physiological and disease processes. To better understand the functions of GPCRs in vivo, we quantified transcript levels of 353 nonodorant GPCRs in 41 adult mouse tissues. Cluster analysis placed many GPCRs into anticipated anatomical and functional groups and predicted previously unidentified roles for less-studied receptors. From one such prediction, we showed that the Gpr91 ligand succinate can regulate lipolysis in white adipose tissue, suggesting that signaling by this citric acid cycle intermediate may regulate energy homeostasis. We also showed that pairwise analysis of GPCR expression across tissues may help predict drug side effects. This resource will aid studies to understand GPCR function in vivo and may assist in the identification of therapeutic targets.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          October 2008
          October 2008
          : 135
          : 3
          : 561-571
          Article
          10.1016/j.cell.2008.08.040
          2590943
          18984166
          © 2008

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