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      Sphingosine-1-phosphate: an enigmatic signalling lipid.

      Nature reviews. Molecular cell biology

      Transcriptional Activation, physiology, metabolism, genetics, analogs & derivatives, Sphingosine, Sphingolipids, Signal Transduction, Receptors, Lysophospholipid, Receptors, G-Protein-Coupled, Receptors, Cell Surface, Plants, Models, Biological, Lysophospholipids, Lipid Metabolism, Ligands, Humans, GTP-Binding Proteins, Cell Movement, Calcium, Apoptosis, Animals

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          Abstract

          The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

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          Journal
          10.1038/nrm1103
          12728273

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