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Isolation of CD24high and CD24low/− cells from MCF-7: CD24 expression is positively related with proliferation, adhesion and invasion in MCF-7
Hee Joung Kim ,
Jong Bin Kim ,
Kyung-Min Lee ,
Incheol Shin ,
Wonshik Han ,
Eunyoung Ko ,
Ji-Yeon Bae ,
Dong-Young Noh
December 2007
December 2007
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Abstract
CD24 has been reported to have a role in metastasis of several malignancies including
breast cancer. We investigated the effect of CD24 expression on biologic features
in human breast cancer cells, and found that CD24 expression is associated with more
rapid growth and enhanced ability of adhesion and invasion in MCF-7. The proportion
of cells was higher in synthetic phase and lower in arrestic phase for CD24(high)
than for CD24(low/-) cells. Cyclin D1 and p27 had stronger expressions in CD24(low/-)
cells than CD24(high) cells. These suggested one possible pathway for CD24 effect
on proliferation.