For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
119
references
 Top references
cited by
14
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      93
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Advances in nanomaterials and their applications in point of care (POC) devices for the diagnosis of infectious diseases

      review-article
      Author(s): a , 1 , b , 1 , c , c , c , * , b , * , a , d , e , *
      Publication date (Electronic):
      Journal: Biotechnology Advances
      Publisher: Published by Elsevier Inc.
      Keywords: POC, point-of-care, SARS, severe acute respiratory syndrome, HIV, human immunodeficiency virus, ELISA, enzyme-linked immunosorbent assay, NAT, nucleic acid test, LOD, limit of detection, RT-PCR, real-time polymerase chain reaction, HBV, hepatitis B virus, HCV, hepatitis C virus, ECM, electrochemical, AuNPs, gold nanoparticles, QDs, quantum dots, MWCNTs, multi-walled carbon nanotubes, HEV, hepatitis E virus, RT-LAMP, reverse transcription loop mediated isothermal purification, NMOF, nano metal-organic framework, SPR, Surface Plasmon Resonance, HbsAg, hepatitis B surface antigens, MNPs, Magnetic NanoParticles, MAP, Mycobacterium avium spp. Paratuberculosis, BSA, bovine serum albumin, Infectious diseases, Nanotechnology, Diagnostic tools, Point-of-care (POC), Pathogens

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Nanotechnology has gained much attention over the last decades, as it offers unique opportunities for the advancement of the next generation of sensing tools. Point-of-care (POC) devices for the selective detection of biomolecules using engineered nanoparticles have become a main research thrust in the diagnostic field. This review presents an overview on how the POC-associated nanotechnology, currently applied for the identification of nucleic acids, proteins and antibodies, might be further exploited for the detection of infectious pathogens: although still premature, future integrations of nanoparticles with biological markers that target specific microorganisms will enable timely therapeutic intervention against life-threatening infectious diseases.

          Highlights

          • •

            Point-of-care (POC) devices are meant to improve the diagnosis of diseases.

          • •

            POCs provide shorter assaying times, cost effectiveness, and simple procedures.

          • •

            Nanotechnology-based POCs can be used for the detection of infectious pathogens.

          Related collections

          Most cited references119

          • Record: found
          • Abstract: not found
          • Article: not found

          Surface plasmon resonance sensors for detection of chemical and biological species.

          Jiří Homola (2008)
          Article 0 comments Cited 662 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Antibiotics and antibiotic resistance genes in natural environments.

            Jose L. Muñoz Martinez (2008)
            The large majority of antibiotics currently used for treating infections and the antibiotic resistance genes acquired by human pathogens each have an environmental origin. Recent work indicates that the function of these elements in their environmental reservoirs may be very distinct from the "weapon-shield" role they play in clinical settings. Changes in natural ecosystems, including the release of large amounts of antimicrobials, might alter the population dynamics of microorganisms, including selection of resistance, with consequences for human health that are difficult to predict.
            Article 0 comments Cited 413 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection.

              YunWei Cao, Rongchao Jin, Chad A. Mirkin (2002)
              Multiplexed detection of oligonucleotide targets has been performed with gold nanoparticle probes labeled with oligonucleotides and Raman-active dyes. The gold nanoparticles facilitate the formation of a silver coating that acts as a surface-enhanced Raman scattering promoter for the dye-labeled particles that have been captured by target molecules and an underlying chip in microarray format. The strategy provides the high-sensitivity and high-selectivity attributes of gray-scale scanometric detection but adds multiplexing and ratioing capabilities because a very large number of probes can be designed based on the concept of using a Raman tag as a narrow-band spectroscopic fingerprint. Six dissimilar DNA targets with six Raman-labeled nanoparticle probes were distinguished, as well as two RNA targets with single nucleotide polymorphisms. The current unoptimized detection limit of this method is 20 femtomolar.
              Article 0 comments Cited 408 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Dai Thien Nhan Tram
                Hao Wang
                Sigit Sugiarto
                Tao Li
                Wee Han Ang
                Chengkuo Lee
                Giorgia Pastorin
                Journal
                Journal ID (nlm-ta): Biotechnol Adv
                Journal ID (iso-abbrev): Biotechnol. Adv
                Title: Biotechnology Advances
                Publisher: Published by Elsevier Inc.
                ISSN (Print): 0734-9750
                ISSN (Electronic): 1873-1899
                Publication date PMC-release: 26 September 2016
                Publication date (Print): December 2016
                Publication date (Electronic): 26 September 2016
                Volume: 34
                Issue: 8
                Pages: 1275-1288
                Affiliations
                [a ]Pharmacy Department National University of Singapore, Singapore 117543, Singapore
                [b ]Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering, Drive 3, Singapore 117576, Singapore
                [c ]Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
                [d ]NanoCore, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
                [e ]NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), Singapore 117456, Singapore
                Author notes
                Article
                Publisher ID: S0734-9750(16)30111-2
                DOI: 10.1016/j.biotechadv.2016.09.003
                PMC ID: 7127209
                PubMed ID: 27686397
                SO-VID: 0d1eb7b5-71ac-41d1-83aa-80e320dc0703
                Copyright © © 2016 Published by Elsevier Inc.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 21 October 2015
                Date revision received : 13 July 2016
                Date accepted : 23 September 2016
                Categories
                Subject: Article

                ScienceOpen disciplines: Biotechnology
                Keywords: poc, point-of-care,sars, severe acute respiratory syndrome,hiv, human immunodeficiency virus,elisa, enzyme-linked immunosorbent assay,nat, nucleic acid test,lod, limit of detection,rt-pcr, real-time polymerase chain reaction,hbv, hepatitis b virus,hcv, hepatitis c virus,ecm, electrochemical,aunps, gold nanoparticles,qds, quantum dots,mwcnts, multi-walled carbon nanotubes,hev, hepatitis e virus,rt-lamp, reverse transcription loop mediated isothermal purification,nmof, nano metal-organic framework,spr, surface plasmon resonance,hbsag, hepatitis b surface antigens,mnps, magnetic nanoparticles,map, mycobacterium avium spp. paratuberculosis,bsa, bovine serum albumin,infectious diseases,nanotechnology,diagnostic tools,point-of-care (poc),pathogens
                Data availability:
                ScienceOpen disciplines: Biotechnology
                Keywords: poc, point-of-care, sars, severe acute respiratory syndrome, hiv, human immunodeficiency virus, elisa, enzyme-linked immunosorbent assay, nat, nucleic acid test, lod, limit of detection, rt-pcr, real-time polymerase chain reaction, hbv, hepatitis b virus, hcv, hepatitis c virus, ecm, electrochemical, aunps, gold nanoparticles, qds, quantum dots, mwcnts, multi-walled carbon nanotubes, hev, hepatitis e virus, rt-lamp, reverse transcription loop mediated isothermal purification, nmof, nano metal-organic framework, spr, surface plasmon resonance, hbsag, hepatitis b surface antigens, mnps, magnetic nanoparticles, map, mycobacterium avium spp. paratuberculosis, bsa, bovine serum albumin, infectious diseases, nanotechnology, diagnostic tools, point-of-care (poc), pathogens

                Comments

                Comment on this article

                scite_

                Similar content93

                See all similar

                Cited by14

                See all cited by

                Most referenced authors2,240

                See all reference authors