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      Receptor Binding of 6α-Methylprogesterone in Mouse Kidney

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          6α-Methylprogesterone (6MP) is an androgenic progestin that binds to the androgen receptor. However, results from an in vivo study suggested that 6MP was also bound by a second receptor. In the present study, we found that 6MP was bound in kidney cytosol from adrenalectomized/ovariectomized female mice as well as Tfm/Y mice, which lack androgen receptors. 6MP was bound with high affinity (K<sub>d</sub> = 1.2 × 10<sup>-8</sup> M)by a binder that was present in 7-8 times greater concentration than the androgen receptor and had the specificity of a glucocorticoid receptor. 6MP was bound with similar specificity in liver cytosol. These data indicate that, despite its androgenic effects, 6MP binds primarily to a glucocorticoid receptor in mouse kidney.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 21
          : 4
          : 261-269
          Department of Medicine, Section of Endocrinology, Tufts University, School of Veterinary Medicine, Boston, Mass., USA
          180059 Horm Res 1985;21:261–269
          © 1985 S. Karger AG, Basel

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          Pages: 9


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