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      Toxicity of halloysite clay nanotubes in vivo: a Caenorhabditis elegans study

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          Abstract

          Halloysite nanotubes in the C. elegans foregut (merged enhanced dark-field and fluorescence images).

          Here we investigated the toxicity of halloysite clay nanotubes in vivo employing a Caenorhabditis elegans nematode as a model organism. Using enhanced dark-field microscopy and physiological tests, we found that halloysite is localised exclusively in the alimentary system and does not induce severe toxic effects on nematodes.

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          Finding function in novel targets: C. elegans as a model organism.

          Titus Kaletta, Michael O. Hengartner (2006)
          Despite its apparent simplicity, the nematode worm Caenorhabditis elegans has developed into an important model for biomedical research, particularly in the functional characterization of novel drug targets that have been identified using genomics technologies. The cellular complexity and the conservation of disease pathways between C. elegans and higher organisms, together with the simplicity and cost-effectiveness of cultivation, make for an effective in vivo model that is amenable to whole-organism high-throughput compound screens and large-scale target validation. This review describes how C. elegans models can be used to advance our understanding of the molecular mechanisms of drug action and disease pathogenesis.
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            Functional polymer–clay nanotube composites with sustained release of chemical agents

            Yuri Lvov, Elshad Abdullayev (2013)
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              Enlargement of halloysite clay nanotube lumen by selective etching of aluminum oxide.

              Elshad Abdullayev, Anupam Joshi, Wenbo Wei … (2012)
              Halloysite clay tubes have 50 nm diameter and chemically different inner and outer walls (inner surface of aluminum oxide and outer surface of silica). Due to this different chemistry, the selective etching of alumina from inside the tube was realized, while preserving their external diameter (lumen diameter changed from 15 to 25 nm). This increases 2-3 times the tube lumen capacity for loading and further sustained release of active chemical agents such as metals, corrosion inhibitors, and drugs. In particular, halloysite loading efficiency for the benzotriazole increased 4 times by selective etching of 60% alumina within the tubes' lumens. Specific surface area of the tubes increased over 6 times, from 40 to 250 m(2)/g, upon acid treatment.
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                Author and article information

                Journal
                Journal ID (publisher-id): ESNNA4
                Title: Environmental Science: Nano
                Abbreviated Title: Environ. Sci.: Nano
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Print): 2051-8153
                ISSN (Electronic): 2051-8161
                Publication date Created: 2015
                Publication date (Print): 2015
                Volume: 2
                Issue: 1
                Pages: 54-59
                Article
                DOI: 10.1039/C4EN00135D
                SO-VID: 0d2abaf5-682b-4529-88a8-2dc8f305ec21
                Copyright © © 2015
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