Reliability of the Minto model for target-controlled infusion of remifentanil during cardiac surgery with cardiopulmonary bypass.

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Abstract

The Minto pharmacokinetic model is used for target-controlled infusion of remifentanil. The reliability of this model has never been evaluated during normothermic cardiac surgery with cardiopulmonary bypass (CPB). The aim of this study was to assess the predictive performance of the model during CPB to determine its reliability during cardiac surgery.

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Journal

Journal ID (iso-abbrev): Br J Anaesth

Title: British journal of anaesthesia

Publisher: Elsevier BV

ISSN (Electronic): 1471-6771

ISSN (Print): 0007-0912

Publication date (Electronic): Aug 2022

Volume: 129

Issue: 2

Affiliations

[1 ] Rouen University Hospital, Department of Anaesthesiology and Critical Care, Rouen, France.

[2 ] Rouen University Hospital, Department of Pharmacology, Rouen, France; Normandie Univ, UNIROUEN, Inserm U1096, EnVi, Rouen, France.

[3 ] Rouen University Hospital, Department of Biostatistics, Rouen, France.

[4 ] Rouen University Hospital, Department of Anaesthesiology and Critical Care, Rouen, France; Normandie Univ, UNIROUEN, Inserm U1096, EnVi, Rouen, France.

[5 ] Normandie Univ, UNIROUEN, Inserm U1096, EnVi, Rouen, France; Rouen University Hospital, Department of Cardiac Surgery, Rouen, France.

[6 ] Rouen University Hospital, Department of Pharmacology, Rouen, France.

[7 ] Rouen University Hospital, Department of Anaesthesiology and Critical Care, Rouen, France; Normandie Univ, UNIROUEN, INSERM U1239, Rouen, France.

[8 ] Rouen University Hospital, Department of Anaesthesiology and Critical Care, Rouen, France; Normandie Univ, UNIROUEN, Inserm U1096, EnVi, Rouen, France. Electronic address: Emmanuel.besnier@chu-rouen.fr.

Article

Publisher Item ID: S0007-0912(22)00238-0

DOI: 10.1016/j.bja.2022.05.003

PubMed ID: 35750514

SO-VID: 0d4f8322-771f-4324-ada3-a99f496f23d5

History

Keywords: cardiac surgery,target-controlled infusion,remifentanil,pharmacokinetic,cardiopulmonary bypass

Data availability:

Keywords: cardiac surgery, target-controlled infusion, remifentanil, pharmacokinetic, cardiopulmonary bypass

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