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      Progress and opportunities for tissue-engineered skin.

      Nature

      physiology, Wound Healing, trends, methods, adverse effects, Tissue Engineering, Skin Pigmentation, therapy, surgery, pathology, Skin Diseases, cytology, Skin, Melanoma, Humans, Dermatologic Surgical Procedures, Animals

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          Abstract

          Tissue-engineered skin is now a reality. For patients with extensive full-thickness burns, laboratory expansion of skin cells to achieve barrier function can make the difference between life and death, and it was this acute need that drove the initiation of tissue engineering in the 1980s. A much larger group of patients have ulcers resistant to conventional healing, and treatments using cultured skin cells have been devised to restart the wound-healing process. In the laboratory, the use of tissue-engineered skin provides insight into the behaviour of skin cells in healthy skin and in diseases such as vitiligo, melanoma, psoriasis and blistering disorders.

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          Author and article information

          Journal
          10.1038/nature05664
          17314974

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