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      Effects of Mucin Ophthalmic Solution on Epithelial Wound Healing in Rabbit Cornea

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          To test the hypothesis that a mucin ophthalmic solution could accelerate the healing of corneal epithelium, we conducted a study in rabbits using an ophthalmic solution containing mucin extracted from bovine submaxillary gland. The corneas of rabbits were abraded with a razor blade in the central portion over an area demarcated with a 7-mm trephine. Mucin-containing eye drops were instilled into the right eye 4 times a day for 3 days, and the vehicle was instilled into the left eye. After enucleation, the eyes were observed by scanning and transmission electron microscopy as well as light microscopy. Mucin-containing eye drops were shown to reduce the epithelial defect area more rapidly than the vehicle. Thus, the eye drops accelerated corneal epithelial wound healing.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 29
          : 2
          : 61-66
          Department of Ophthalmology, Fujita Health University, School of Medicine, Aichi, Japan
          267998 Ophthalmic Res 1997;29:61–66
          © 1997 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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