Changes in the Concentration of LH, FSH and Estrogen in the Immature Female Rat during Precocious Sexual Maturation Induced by Electrochemical Stimulation of the Brain

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Abstract

Electrochemical stimulation of the hypothalamus of 23-day-old female rats induced precocious puberty as judged by occurrence of vaginal opening, the degree of uterine hypertrophy, changes in ovarian steroid content and incidence of first ovulation. Three types of responses were observed: (I) pubertal ovulation within 96 h; (II) pubertal ovulation within 120 h, and (HI) vaginal opening at 120 h not followed by ovulation. All treated animals showed a sustained increase in the LH/FSH ratio in both pituitary and plasma. Plasma estrogen was also increased 1 h after stimulation. A preovulatory rise in plasma estrogen and gonadotrophins was noted in type I and type II animals. These data lend further support to the suggestion that brain stimulation causes a release of gonadotrophins which induce ovarian steroidogenesis leading to an ovulatory gonadotrophin surge via a positive feedback effect.

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Journal ID (publisher-id): HRE

Journal ID (doi): 10.1159/issn.0018-5051

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 0018-5051

ISSN (Electronic): 2571-6603

Publication date Subscription-year: 1976

Publication date (Print): 1976

Publication date (Electronic): 21 November 2008

Volume: 7

Issue: 1

Pages: 34-42

Affiliations

Departments of Obstetrics and Gynecology and of Neurosciences, McMaster University, Health Sciences Centre, Hamilton, Ont.

Article

Publisher ID: 178706 Other ID: Horm Res 1976;7:34–42

DOI: 10.1159/000178706

SO-VID: 0d769e92-e1ef-497f-92d0-e196168407a1

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Changes in the Concentration of LH, FSH and Estrogen in the Immature Female Rat during Precocious Sexual Maturation Induced by Electrochemical Stimulation of the Brain

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Karger: Endocrinology

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