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      Changes in the Concentration of LH, FSH and Estrogen in the Immature Female Rat during Precocious Sexual Maturation Induced by Electrochemical Stimulation of the Brain

      , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Puberty, Brain lesions, Gonadotrophins, Plasma estrogen

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          Abstract

          Electrochemical stimulation of the hypothalamus of 23-day-old female rats induced precocious puberty as judged by occurrence of vaginal opening, the degree of uterine hypertrophy, changes in ovarian steroid content and incidence of first ovulation. Three types of responses were observed: (I) pubertal ovulation within 96 h; (II) pubertal ovulation within 120 h, and (HI) vaginal opening at 120 h not followed by ovulation. All treated animals showed a sustained increase in the LH/FSH ratio in both pituitary and plasma. Plasma estrogen was also increased 1 h after stimulation. A preovulatory rise in plasma estrogen and gonadotrophins was noted in type I and type II animals. These data lend further support to the suggestion that brain stimulation causes a release of gonadotrophins which induce ovarian steroidogenesis leading to an ovulatory gonadotrophin surge via a positive feedback effect.

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          Author and article information

          Journal
          HRE
          10.1159/issn.0018-5051
          Hormone Research in Paediatrics
          S. Karger AG
          0018-5051
          2571-6603
          1976
          1976
          21 November 2008
          : 7
          : 1
          : 34-42
          Affiliations
          Departments of Obstetrics and Gynecology and of Neurosciences, McMaster University, Health Sciences Centre, Hamilton, Ont.
          Article
          178706 Horm Res 1976;7:34–42
          10.1159/000178706
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Paper

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