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Inorganic-Organic Hybrid Nanomaterials for Therapeutic and Diagnostic Imaging Applications

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      Abstract

      Nanotechnology offers outstanding potential for future biomedical applications. In particular, due to their unique characteristics, hybrid nanomaterials have recently been investigated as promising platforms for imaging and therapeutic applications. This class of nanoparticles can not only retain valuable features of both inorganic and organic moieties, but also provides the ability to systematically modify the properties of the hybrid material through the combination of functional elements. Moreover, the conjugation of targeting moieties on the surface of these nanomaterials gives them specific targeted imaging and therapeutic properties. In this review, we summarize the recent reports in the synthesis of hybrid nanomaterials and their applications in biomedical areas. Their applications as imaging and therapeutic agents in vivo will be highlighted.

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           M Bruchez,  M Moronne,  P Gin (1998)
          Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.
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            Author and article information

            Affiliations
            [1 ] Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
            [2 ] Department of Bioenvironmental Engineering, Chung Yuan Christian University, Chung Li, 32023, Taiwan; E-Mail: yt_huang@ 123456cycu.edu.tw
            Author notes
            [* ]Author to whom correspondence should be addressed; E-Mail: jlvivero@ 123456email.unc.edu ; Tel.: +1-919-448-1752.
            [†]

            These authors contributed equally to this work.

            Journal
            Int J Mol Sci
            ijms
            International Journal of Molecular Sciences
            Molecular Diversity Preservation International (MDPI)
            1422-0067
            2011
            10 June 2011
            : 12
            : 6
            : 3888-3927
            3131598
            21747714
            10.3390/ijms12063888
            ijms-12-03888
            © 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

            This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

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