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      Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee

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          Abstract

          <p class="first" id="d3411919e164">The ISA Nomenclature Committee met electronically before and directly after the XVII ISA International Symposium on Amyloidosis, which, unfortunately, had to be virtual in September 2020 due to the ongoing COVID-19 pandemic instead of a planned meeting in Tarragona in March. In addition to confirmation of basic nomenclature, several additional concepts were discussed, which are used in scientific amyloid literature. Among such concepts are cytotoxic oligomers, protofibrils, primary and secondary nucleation, seeding and cross-seeding, amyloid signature proteins, and amyloid plaques. Recommendations for their use are given. Definitions of amyloid and amyloidosis are confirmed. Possible novel human amyloid fibril proteins, appearing as 'classical' in vivo amyloid, were discussed. It was decided to include fibulin-like extracellular matrix protein 1 (amyloid protein: AEFEMP1), which appears as localised amyloid in portal veins. There are several possible amyloid proteins under investigation, and these are included in a new Table. </p>

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          Author and article information

          Journal
          Amyloid
          Amyloid
          Informa UK Limited
          1350-6129
          1744-2818
          October 01 2020
          October 26 2020
          October 01 2020
          : 27
          : 4
          : 217-222
          Affiliations
          [1 ]Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
          [2 ]Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
          [3 ]Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA
          [4 ]Amyloid Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, and University of Pavia, Pavia, Italy
          [5 ]Institute of Molecular and Cellular Biology, University of Porto, Molecular Neurobiology, Porto, Portugal
          [6 ]Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan
          [7 ]Department of Biochemistry (Retired), Boston University School of Medicine, Boston, MA, USA
          [8 ]Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
          Article
          10.1080/13506129.2020.1835263
          33100054
          0d8fc9d3-da13-4213-9404-7de2bef14ef6
          © 2020

          http://creativecommons.org/licenses/by-nc-nd/4.0/

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