Chaihu Longgu Muli decoction, a Chinese herbal formula, for the treatment of insomnia

Author(s): Xinyi Wang , MM ^a ^, ^b ^, ^c , Jianqing Ju , MD, PHD ^b ^, ^c , Jingen Li , MD, PHD ^d , Yixuan Fan , MM ^a ^, ^b ^, ^c , Hao Xu , MD, PHD ^b ^, ^c ^, ^∗

Editor(s): In-Hyuk Ha.

Publication date (Electronic): 02 October 2020

Journal: Medicine

Publisher: Lippincott Williams & Wilkins

Keywords: Chaihu Longgu Muli decoction, insomnia, Chinese herbal medicine, systematic review

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Abstract

Purpose:

To review the literature on the efficacy and safety of Chaihu Longgu Muli decoction (CLMD) for insomnia.

Methods:

A systematic literature search was performed for five databases up to May of 2019 to identify randomized control trials involving CLMD for patients with insomnia. The experimental group was CLMD monotherapy or CLMD plus conventional treatment. Comparators were placebo, no treatment, or conventional medicine. The main comparison was CLMD against conventional drugs. The primary outcome was sleep quality (assessed using the Pittsburgh Sleep Quality Index, PSQI). The secondary outcomes were clinical effectiveness rate, total sleep time, and adverse event rate. RevMan 5.3 software was used for meta-analysis with effect estimate presented as relative risk (RR) and mean difference (MD) with 95% confidence interval (CI).

Results:

A total of 22 studies involving 2029 patients were included. All the included studies presented some risk of bias, especially risks of performance, and detection bias. The main meta-analysis showed that CLMD alone was more effective than conventional medications by reducing PSQI (MD = −2.80, 95% CI [−5.48, −0.13], P = .04), improving the clinical effectiveness rate (RR = 1.23, 95% CI [1.16, 1.31], P < .00001), and prolonging total sleep time (MD = 1.01, 95% CI [0.19, 1.83], P = .002). The adverse event rate in the CLMD group was lower than that of the control group (RR = 0.22, 95% CI [0.09, 0.51], P = .0005). CLMD also improved sleep quality better than conventional medications as an adjunct therapy ( P < .05). The funnel plot was symmetrical, representing a low risk of publication bias.

Conclusion:

CLMD presented better efficacy and safety than conventional medications and had the potential to become an alternative to conventional medications for the treatment of insomnia. However, as the included studies showed significant risks of bias, these results will need to be confirmed by future double-blind randomized controlled trials.

PROSPERO registration number:

CRD42019133103.

Related collections

Most cited references 50

Record: found
Abstract: found
Article: not found

Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians.

Amir Qaseem, Devan Kansagara, Mary Forciea … (2016)

The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the management of chronic insomnia disorder in adults.

0 comments Cited 425 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Psychometric evaluation of the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI) in primary insomnia and control subjects.

Pei-Shan Tsai, Shu-Yi Wang, Mei-Yeh Wang … (2005)

In order to effectively study the population experiencing insomnia, it is important to identify reliable and valid tools to measure sleep that can be administered in the home setting. The purpose of this study was to assess psychometric properties for the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI) in community-dwelling adults with primary insomnia. The CPSQI had an overall reliability coefficient of 0.82 -0.83 for all subjects. "Subjective sleep quality" was the component most highly correlated with the global score. Overall, the CPSQI showed acceptable test-retest reliability over a 14- to 21-day interval with a coefficient of 0.85 for all subjects and 0.77 for primary insomniacs. The two contrasting groups had significantly different global and component scores. A CPSQI of greater than 5 yielded a sensitivity and specificity of 98 and 55% in primary insomniacs vs. controls. A CPSQI of greater than 6 resulted in a sensitivity and specificity of 90 and 67%. Results suggest that the CPSQI is a psychometrically sound measure of sleep quality and disturbance for patients with primary insomnia. It may not be an effective screening tool because of its low specificity, but it can be a sensitive, reliable, and valid outcome assessment tool for use in community-based studies of primary insomnia.

0 comments Cited 348 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Chronic insomnia.

Charles Morin, Ruth M. Benca (2012)

Insomnia is a prevalent complaint in clinical practice that can present independently or comorbidly with another medical or psychiatric disorder. In either case, it might need treatment of its own. Of the different therapeutic options available, benzodiazepine-receptor agonists (BzRAs) and cognitive-behavioural therapy (CBT) are supported by the best empirical evidence. BzRAs are readily available and effective in the short-term management of insomnia, but evidence of long-term efficacy is scarce and most hypnotic drugs are associated with potential adverse effects. CBT is an effective alternative for chronic insomnia. Although more time consuming than drug management, CBT produces sleep improvements that are sustained over time, and this therapy is accepted by patients. Although CBT is not readily available in most clinical settings, access and delivery can be made easier through use of innovative methods such as telephone consultations, group therapy, and self-help approaches. Combined CBT and drug treatment can optimise outcomes, although evidence to guide clinical practice on the best way to integrate these approaches is scarce. Copyright Â© 2012 Elsevier Ltd. All rights reserved.

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Author and article information

Journal

Journal ID (nlm-ta): Medicine (Baltimore)

Journal ID (iso-abbrev): Medicine (Baltimore)

Journal ID (publisher-id): MEDI

Title: Medicine

Publisher: Lippincott Williams & Wilkins (Hagerstown, MD )

ISSN (Print): 0025-7974

ISSN (Electronic): 1536-5964

Publication date Collection: 02 October 2020

Publication date (Electronic): 02 October 2020

Volume: 99

Issue: 40

Electronic Location Identifier: e22462

Affiliations

[a ]Graduate School, Beijing University of Chinese Medicine

[b ]Cardiovascular Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

[c ]National Clinical Research Center for Chinese Medicine Cardiology

[d ]Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Author notes

[∗ ]Correspondence: Hao Xu, National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No.1, Xiyuan Playground, Haidian District, Beijing 100091, China (e-mail: xuhaotcm@ 123456hotmail.com ).

Article

Publisher ID: MD-D-20-00712 Accession ID: 22462

DOI: 10.1097/MD.0000000000022462

PMC ID: 7535661

PubMed ID: 33019437

SO-VID: 0d936f62-f7a2-4e29-aa83-6effdcdcc48d

License:

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0

History

Date received : 25 January 2020

Date revision received : 27 May 2020

Date accepted : 29 August 2020

Funding

Funded by: Capital's Funds for Health Improvement and Research

Award ID: 2018-1-4171

Award Recipient : hao xu

Funded by: Special Project for Professional Construction of National Clinical Research Center of Traditional Chinese Medicine

Award ID: NO. JDZX2015263

Award Recipient : hao xu

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Keywords: chaihu longgu muli decoction,insomnia,chinese herbal medicine,systematic review

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Keywords: chaihu longgu muli decoction, insomnia, chinese herbal medicine, systematic review

Chaihu Longgu Muli decoction, a Chinese herbal formula, for the treatment of insomnia : A systematic review and meta-analysis